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As a first line of treatment, systemic and targeted therapies predominantly include tyrosine kinase inhibitors (TKIs) such as sorafenib (Nexavar), an oral medication that inhibits multiple tyrosine kinases, lenvatinib (Lenvima), an alternative to sorafenib, and regorafenib (Stivarga) and cabozantinib (Cabometyx), used as second line of treatment for patients who have progressed on sorafenib [13,14,15,16,17,18,19]